Interestingly, previous studies have found that the exogenous expression of BubR1 induces apoptosis and inhibits expansion of tumours established with BubR1-depleted aneuploid cells in mice [24] and that BubR1 triggers the intrinsic apoptotic pathway upstream of caspase-9, thereby activating caspase-3 [24, 38, 39]. This evidence concerns the gene CASP3 and neoplasm.