CCND1 and breast carcinoma: To date, several meta-analyses have demonstrated that various biomarkers may be associated with the survival of patients with breast cancer, including p27 [35], vascular endothelial growth factor (VEGF) [36], Cyclooxygenase (COX-2) [37], B cell lymphoma 2 protein (BCL-2) [38], and cyclin D1 [39].