MTHFR and ischemic stroke: The combined effect of the MTHFR TT genotype and the EPHX2 GG or GA + AA genotype was found to have a higher risk of ischemic stroke compared with the control group (combined effect of MTHFR CC genotype and EPHX2 GA + AA genotype: OR = 3.46 and OR = 3.42, resp.; P = .001 and P = .002, resp).