The high Myc/low NFκB state that occurs during latency IIb might play a role in immune evasion as elevated Myc and low NFκB as observed in BL have been implicated in downregulation of MHC class I and II (MHC-I and MHC-II) and avoidance of T-cell recognition and killing29,30. The gene discussed is MYC; the disease is Burkitt lymphoma.