IL1B and hypertensive disorder: Moreover, TREM-1 (that mediates inflammatory cardiac injury) [34], CINC2 (CXCL-3) that is induced by IL-1 (and also called macrophage inflammatory protein 2 beta, MIP-2β) [35], and fibroblast growth factor binding protein (FGF-BP) (that is implicated in hypertension) [36] were also suppressed in ZO-C heart (Figure 4).