LEP and obesity due to melanocortin 4 receptor deficiency: Higher plasma leptin concentrations (32.4 ± 4.1 versus 29.0 ± 4.4 mg/dL) and lower adiponectin levels (9.54 ± 1.33 versus 7.90 ± 1.08 μg/dL) were highlighted suggesting increased obesity-related complications.