Neuron survival after such ischemic brain injury has been shown to be mediated by regulation of cAMP response element- (CRE-) mediated gene expressions, including cAMP response binding protein (Creb) [14], brain-derived neurotrophic factor (Bdnf) [15], and B-cell lymphoma 2 (Bcl-2) [16] expressions. Here, CREB1 is linked to brain injury.