CFTR and congenital bilateral aplasia of vas deferens from CFTR mutation: The CF mutation induces a severe phenotype involving different organs, whereas a CFTR-RD mutation induces less life-threatening symptoms with three main clinical entities including congenital bilateral absence of the vas deferens (CBAVD), acute recurrent or chronic pancreatitis, and disseminated bronchiectasis (Bombieri et al., 2011).