In contrast, TET2 is clearly a tumor suppressor in all hematopoietic cell types reported so far, since deletions and loss-of-function mutations in the TET2 gene are strongly associated with myelodysplastic syndromes, myeloproliferative neoplasms, and myeloid leukemias as well as lymphoid malignancies (126, 127). Here, TET2 is linked to myeloproliferative disorder.