TP53 and mature T-cell and NK-cell non-Hodgkin lymphoma: Consistent with antigen-dependent expansion, development of iNKT cell PTCL in p53-deficient mice was accelerated by repeated injections with heat-killed bacteria expressing glycolipid antigens, and diminished by treatment of mice with anti-CD1d or cyclosporin A, a compound that interferes with TCR signaling by inhibiting the calcineurin/NFAT pathway (133).