MAPT and Alzheimer disease: For many scientists and pharmaceuticals companies, there are several and different treatment approaches for AD such as cholinesterase inhibitors, NMDA receptor antagonist, β-secretase inhibitors, γ-secretase inhibitors, α-secretase stimulators, tau inhibitors, immunotherapy, nutraceuticals, and nano drugs (Ashraf et al., 2015; Soursou et al., 2015) even though the more secure solution seems to be the early diagnosis of neurodegeneration signs, in order to facilitate the early diagnosis or prediction.