Because several proteins involved in neurodegenerative diseases bear one or more Akt consensus sites, alterations in the balance between phosphorylation by Akt and arginine methylation by the PRMTs could have major effects on neurotoxicity not only in SBMA, but also in other neurodegenerative diseases (Basso and Pennuto, 2015). This evidence concerns the gene AKT1 and neurodegenerative disease.