TARDBP and proteostasis deficiencies: Depending on the aethiologic agent that forms aggregates and on the type of aggregate, brain folding diseases can be subdivided into four types of proteinopathies, namely amyloidoses, tauopathies, α-synucleinopathies, and transactivation response-DNA binding protein 43 (TDP-43) proteinopathies (reviewed by Dugger and Dickson, 2017).