MAPT and Alzheimer disease: In the past years, emerging evidence for a consistent regional deposition pattern of in vivo tau PET ligands in AD supports a typical involvement of the inferior and lateral temporal lobes, precuneus and posterior cingulate, as well as occipital and lateral parietal lobes (Brier et al., 2016; Ishiki et al., 2015; Johnson et al., 2016; Ossenkoppele et al., 2016; Schwarz et al., 2016).