However, spatial correspondence of the two imaging modalities was far from being complete (r = −0.49 to −0.60), and future studies will have to further explore similarities and differences in the in vivo spatial distribution profiles of AD-related tau pathology and neurodegeneration, as well as their respective relations to the spatial topography of intrinsic brain networks (Sepulcre et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.