The role of MBL in the development of cirrhosis is related to increased hepatotoxic damage, and its origin is attributed to viral infection and/or immunodeficiency associated with MBL2 alleles that affect liver pathology [17, 18]. MBL2 gene mutations have been related to the progression of the infection to the chronic phase, with the development of cirrhosis and hepatocellular carcinoma, and to the different responses to therapy [19, 20]. The gene discussed is MBL2; the disease is Immunodeficiency.