The present study investigated the frequencies of MBL2 gene polymorphisms MBL∗D (rs5030737, C>T), MBL∗B (rs1800450, G>A), and MBL∗C (rs1800451, G>A) in patients with chronic hepatitis B and C viral infections and the correlation with laboratory markers of inflammation and structural changes in the liver parenchyma. The gene discussed is MBL2; the disease is viral infectious disease.