SETX and amyotrophic lateral sclerosis type 4: The human orthologue of yeast Sen1, senataxin (SETX), is associated with neurological pathologies: recessive mutations in the SETX gene cause ataxia with oculomotor apraxia type 2 (AOA2) and dominant mutations provoke amyotrophic lateral sclerosis type 4 (ALS4) (reviewed in Bennett & La Spada, 2015).