ABCD1 and adrenomyeloneuropathy: Inactivation of Abcd1 in mice, associated with human adrenoleukodystrophy (ALD), leads to a late-onset neurological phenotype that resembles adrenomyeloneuropathy, with abnormal myelin and axonal loss in the spinal cord and the sciatic nerve, but these mice do not display the cerebral demyelination characteristic of cerebral ALD [46].