The accumulation within abnormal muscle fibers of several pathologic and Alzheimer-related proteins such as beta-amyloid precursor protein (beta-APP), phosphorylated tau, alpha-1-antichymotrypsin, apolipoprotein E and presenilin-1 is an unusual feature of sporadic inclusion-body myositis (sIBM) [25]. Here, PSEN1 is linked to inclusion body myositis.