In a Klotho-deficient mouse aging-model study, Kuro-o et al. reported that Klotho deficiency is closely related to cardiovascular diseases, such thatit enhances arteriosclerosis, extensive medial calcification of the aorta, and medial calcification and intimal thickening of medium-sized muscular arteries [9]. This evidence concerns the gene KL and arteriosclerosis disorder.