No statistically significant increased odds of serious infection were observed for any other treatment comparisons including those between the specific anti-TNFs agents (i.e. adalimumab vs. infliximab), as well as those between anti-TNF monotherapy and dual therapy with an immunomodulator (i.e. infliximab alone vs. infliximab + azathioprine/6MP) (Additional file 3: Table S3). The gene discussed is TNF; the disease is infection.