The mRNA levels for two confirmed Klf9 targets that are classified as Wnt-pathway related and are implicated in promoting mitosis, B cell CLL/Lymphoma 6 (Bcl-6) and inositol triphosphate receptor 3 (Itpr3), were significantly elevated in both CRISPR lines (Fig. 7d; Bcl-6: F(2,9) = 19.797, p = 0.001; Iprt3: F(2,9) = 13.346, p = 0.002; n = 6/cell line; ANOVA). This evidence concerns the gene ITPR3 and B-cell chronic lymphocytic leukemia.