EGFR and non-small cell lung carcinoma: It significantly lost activity against EGFR wt expressing NSCLC cell lines such as A549( GI50: 5.4μM), H1355 (GI50: 8.1 μM), H2122 (GI50: 3.5 μM ) and H1703 (GI50: 7.7 μM), which is in the similar trend as AZD9291.