Moreover, the reduction of PAK4 expression led to a dramatic inhibition of tumor cell migration (Figure 3C, 4.26-fold PAK4 siRNA #2, p < 0.001; 3.88-fold PAK4 siRNA #3, p < 0.01) and invasion (Figure 3D, 4.08-fold PAK4 siRNA #2; 3.76-fold PAK4 siRNA #3, both p < 0.01). The gene discussed is PAK4; the disease is neoplasm.