However, in both RA and SLE, the median (range) frequency of CD3−CD56+CD107a+ activated NK cells was significantly higher in samples incubated with OBZ compared with RTX, 5.1% (1.9–22%) vs 2.8% (0.3–14%) and 5.5% (0.6–12%) vs 4.3% (1.2–8.9%), respectively, and the median (range) frequency of CD16+ NK cells was significantly lower, 69% (36–94%) vs 89% (83–97%) and 66% (42–91%) vs 84% (61–95%), respectively (Fig. 3B). This evidence concerns the gene FCGR3A and rheumatoid arthritis.