OBZ was more efficient than OBZGly and RTX in depleting B cells in the whole blood assay in both RA (n = 18) and SLE (n = 23) (Fig. 4A) with an increasing hierarchy in the frequency of, and fold-increase in, CD3−CD56+CD107a+ NK cells as follows: no mAbs = OBZ-PG LALA > RTX > OBZGly > OBZ (Fig. 4B–D). Here, LAMP1 is linked to rheumatoid arthritis.