Thus, the ability of mAbs to up-regulate the expression of CD107a on CD3−CD56+ NK cells was greater in RA compared with SLE, such that the mean fold difference in samples incubated with RTX, OBZ-PG LALA, OBZGly and OBZ compared with samples incubated without mAbs was 1.2, 1.5, 1.9 and 3.1, respectively, in RA and 1.5, 0.8, 1.4 and 1.8, respectively, in SLE (Fig. 4C). The gene discussed is LAMP1; the disease is systemic lupus erythematosus.