CD28 and infection: Additionally, the supervised analysis yielded aberrancies in the normal functioning of the TCRγδ+ T-LGL lymphoproliferative cells, with more skewing towards activation and inflammation given the up-regulation of CD28 and CCR7. IFNG on the other hand was down-regulated, implying that normal functioning of TCRγδ+ T cells through IFN-γ production upon activation during infection [38], is lost.