KDM6B and disease arising from reactivation of latent virus: Lastly, but importantly, in monocytic cells where CMV establishes latent infection, but not in fibroblast or epithelial cells, JMJD3 was induced upon monocyte transdifferentiation into macrophages and dendritic cells, concomitant with viral reactivation.[56, 57] All these observations promoted us to further examine if H3K27 demethylase JMJD3 plays a critical role in hCMV lytic infection and reactivation, and our results strongly suggest this is the case.