Additionally, in another study using HSV-1 mouse model, LSD1 inhibitor tranylcypromine was shown to reduce the in vivo viral IE gene expression, decrease the severity of wild type-virus-induced encephalitis (with reduced inflammatory infiltrates) and corneal blindness, block the infection with the acyclovir-resistant HSV-1 mutant, and reduce the in vivo viral reactivation in trigeminal ganglia[59]. This evidence concerns the gene KDM1A and infection.