In the Hyp mouse homolog of X-linked hypophosphatemic rickets/osteomalacia, a model with impaired bone mineralization, NaCT mRNA expression was decreased in bone, and this was thought to deprive osteoblasts of citrate and increase local extracellular citrate levels, which may have contributed to impaired mineralization [21]. Here, SLC13A5 is linked to X-linked hypophosphatemic rickets.