The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene, represents the most common pathogenic mutation identified in PD worldwide, accounting for up to 1–6% of sporadic and 3–19% of familial PD with even higher frequencies in Ashkenazi Jews (AJ) (16% in sporadic and 30% if familial patients) [9–11]. Here, LRRK2 is linked to Parkinson disease.