BICC1 and Cystic renal dysplasia: Taken together, our findings are congruent with studies of vertebrate BicC: BicC function is needed for kidney homeostasis in vertebrates, mutations cause renal cysts in zebrafish, Xenopus and mice [16,19,26], and two BicC mutations were found in patients with infantile, unilateral renal cystic dysplasia [17].