TRIB1 has been identified as oncogene that mediates oncogenesis through the MEK–ERK pathway, GRP78–Akt pathway and C/EBP regulation.12, 13, 14 In the present study, our GSEA analysis data demonstrated that TRIB1, as MAPK pathway related gene, was upregulated by CDDP pretreatment in NSCLC cells. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.