More importantly, the combined silence of HDAC1 and TRIB1 could completely block CDDP-induced cell migration, improve sensitivity to CDDP, and reduce the expressions of CSCs transcription factors, especially for Oct4, in NCI-H460 cells (Figures 4f–h), indicating the possibility that HDAC1 and TRIB1 cooperatively mediate CDDP-induced CSCs enrichment and resistance in NSCLC cells. Here, POU5F1 is linked to non-small cell lung carcinoma.