FASLG and Acute hepatitis: Injection of the lectin ConA into mice induces the activation of liver-homing T cells and NK cells, expression of FasL and consequently killing of sinusoidal endothelial cells and hepatocytes.31 This ultimately leads to acute hepatitis, as evidenced by areas of extensive tissue damage in the liver, and increased serum transaminases (Figures 7a, c, f, g).32 FasL dependency of ConA-induced hepatotoxicity was confirmed by the reduced liver damage of FasL mutant gld mice (Figure 7a).5