FASLG and autoimmune disease: Accordingly, FasL mutant gld mice show defects in T-cell homeostasis, severe lymphoproliferative disorders and autoimmune diseases.5 Furthermore, FasL is recognized as an important cytotoxic effector molecule, particularly involved in the induction of tissue damage during immunopathological disorders, such as acute Graft-versus-Host disease11 and hepatitis, as shown here (Figure 7a).32