Importantly, while ConA treatment alone resulted in extensive liver damage as evidenced by a profound increase in serum transaminases, caspase 3 activation, apoptosis and histological liver damage, pretreatment of mice for 1 h with 3d2 almost completely abrogated all signs of liver damage and hepatitis (Figures 7c–g). The gene discussed is CASP3; the disease is hepatitis A virus infection.