Previous studies have shown that WDR79 (WRAP53β) protein cannot regulate p53 expression.44 Intriguingly, we found although WDR79 protein did not affect the transcription of p53 mRNA, it could stabilize p53 protein by interacting with deubiquitinating enzyme USP7 via the ubiquitin proteasome system in the A549 NSCLC cell line. Here, USP7 is linked to non-small cell lung carcinoma.