USP7, a member of the USP family, is first defined as Herpes virus associated cellular factor (HAUSP) and is critical for genome stability, epigenetic regulation, cell cycle, apoptosis, viral infection immunity and stem cell maintenance.16, 17, 18, 19, 20 Clinically, USP7 is reportedly associated with tumorigenesis, including prostate cancer, multiple myeloma cancer, ovarian cancer, breast cancer and NSCLC.20, 21, 22, 23, 24. This evidence concerns the gene USP7 and viral infectious disease.