Specifically, germline mutations in WDR79 that affect the WD-repeat domain result in congenital dyskeratosis,9 and WDR79 overexpression has been observed in rectal cancer,10 head and neck carcinomas,11 squamous cell carcinoma,12 breast cancer13 and ovarian cancer.14 In a previous study, we also found that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung cancer (NSCLC) and accelerates NSCLC cell proliferation.15 However, the detailed mechanism underlying the effect of WDR79 on the proliferation of NSCLC cells remains unclear. Here, WRAP53 is linked to rectal cancer.