Although both miR-21 ablation or OCA supplementation resulted in a modest decrease in steatosis, the dual activation of PPARα and FXR resulted in markedly reduced lipid accumulation, diffused microvesicular steatosis and a lipidosis score of 2.33 (P<0.05; Figures 2c and d top). This evidence concerns the gene NR1H4 and lysosomal lipid storage disorder.