CCN4 and neoplasm: CCN family proteins are known to affect cell migration by binding to cell surface integrin receptors.26 Our previous research found that WISP-1 increases tumor metastasis and angiogenesis through interaction with a specific receptor integrin αvβ3.27, 28 Therefore, we pretreated cells with cyclic Arg-Gly-Asp (RGD; a specific peptide that has high affinity with αvβ3 integrin) or with cyclic Arg-Ala-Asp (RAD) for 30 min and then stimulated cells with WISP-1 for 24 h.