In adulthood, WISP-1 expression has been observed in the developing skeleton.37 Much evidence has determined that WISP-1 has a key role in tumor cell proliferation, migration, and survival in vitro, as well as tumor growth and metastasis in vivo.11 Our previous research indicated that WISP-1 promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression.28 Here, we found that WISP-1 was up-regulated in human osteosarcoma cells. This evidence concerns the gene CCN4 and osteosarcoma.