In recent years, much research has focused on the role of angiogenesis in osteosarcoma proliferation, development, invasion, and metastasis.34 VEGF-A has been recognized as being a major contributor to angiogenesis.35 In this study, we found that WISP-1 affects VEGF-A production in human osteosarcoma. The gene discussed is CCN4; the disease is osteosarcoma.