Consistent with this idea, overexpression of EZH2 in mice augmented HSC regeneration and prevented the HSC exhaustion during the transplantation assays.32 However, elevation of EZH2 and other PRC2 components is associated with aggressive forms in solid cancers and related to cancer progression.39, 40 As a result, PRC2 inhibition has emerged as a potential strategy cancer treatment strategy, and is currently being tested in clinical trials. This evidence concerns the gene EZH2 and cancer.