FMO5 and intestinal polyp: On the other hand, indomethacin, a cyclooxygenase (COX) inhibitor; nimesulide, a COX-2-selective inhibitor; sesamol, a COX-2 suppressor; and apocynin, an NADPH oxidase inhibitor, have been shown to mainly reduce the number of intestinal polyps in the middle to distal parts of the small intestine [24,25,26,27].