MSH2 and Li-Fraumeni syndrome: Additional germline mutations in BRIP1, BARD1, PALB2, NBN, RAD51B, RAD51C, RAD51D [42,43] as well as MLH1, MSH2, MSH6, PMS2, EPCAM, (all associated with Lynch syndrome [44]), TP53 (associated with Li-Fraumeni syndrome [45]) and STK11/LKB1 (associated with Peutz-Jeghers syndrome [46]) are related to moderately increased risk of ovarian cancer.