Consistent with this notion, mutations in the CAP-Gly domain of p150 – which associates with EB1 – compromise the initiation of retrograde motility in distal axons and are associated with human neurological disease (Farrer et al., 2009; Lloyd et al., 2012; Moughamian and Holzbaur, 2012). Here, MAPRE1 is linked to nervous system disorder.