To evaluate the influence of ROS scavenger upregulation on oxidative stress as well as cardiac function in sepsis, SE and oxidative stress were evaluated between a group of C57BL/6J MCAT+/+ transgenic mice (n = 12), which overexpress mitochondrial-targeted catalase and C57BL/6J WT mice (n = 14) following CLP. The gene discussed is CAT; the disease is Sepsis.