Such key single nucleotide polymorphisms (SNPs) are located in LDLR, APOB, APOE, ABCG8 and SORT1. In more than 80% of those with a clinical diagnosis of FH but with no detectable mutation in LDLR/APOB/PCSK9, the polygenic explanation is most likely. The gene discussed is PCSK9; the disease is familial hyperaldosteronism.