PNPLA5 and familial hyperaldosteronism: Several studies have been conducted to identify new genes causing FH, using family studies and next-generation sequencing (NGS) and this has identified three genes STAP1 (signal transducing adaptor protein family 1), LIPA (lysosomal acid lipase) and PNPLA5 (patatin-like phospholipase-domain-containing family) where mutations may be causing significantly elevated LDL-C and possibly the clinical phenotype of FH [29•, 30, 31].