The efficacy of ranibizumab to treat CNV was investigated in a phase 1, randomized clinical study including a total of 30 patients (9 POHS patients) with CNV due to causes other than age-related macular degeneration and was reported to be effective in these patients.12 Nielsen et al.13 stated that anti-VEGF agents were beneficial in the treatment of CNV related to ocular histoplasmosis syndrome and found that these patients required an average of 4.5 intravitreal injections per year. This evidence concerns the gene VEGFA and age-related macular degeneration.