In contrast to the low G3BP expression generated by these stimuli, type I IFNs induce G3BP gene expression in vitro, and exploratory studies of IFN gene signatures in neutrophils and PBMCs from SLE patients identified G3BP as one of only few highly IFN-inducible genes [66, 74, 75]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.