PPARD and obesity due to melanocortin 4 receptor deficiency: Here we show that PPARδIEC-KO mice display increased sensitivity to diet induced obesity and are unable to increase plasma HDLc levels after stimulation with the PPARδ specific agonist GW501516, indicating that intestinal PPARδ has an important role in the regulation of energy metabolism that cannot be compensated by PPARδ activation in other tissues.