Genetic variants VEGFR2 rs2239702, ABCB1 rs1045642 and ABCB1 rs2032582 were significantly associated with increased risk of HFS and hypertension; ABCB1 rs1128503 was reported associated with increased risk of hypertension; UGT1A1*6 rs4148323 and UGT1A9 were associated with hypertension. The gene discussed is UGT1A1; the disease is Hand-foot syndrome.