As previously mentioned in this report, the earliest hint of triazene-induced DIX in human neoplasias was obtained by D’Atri et al. in 1994 [11] who found that selected CD8+ CTL clones directed against in vitro triazene-treated H-125 human lung adenocarcinoma cell line were able to lyse the drug-treated cells but not the untreated parental cells. This evidence concerns the gene CD8A and neoplasm.