PHB1 and esophageal squamous cell carcinoma: In summary, we provided a better understanding of the biology of ESCC carcinogenesis by PHBP1. We investigate that the PHBP1 was significantly upregulated in ESCC tissues and increased expression of PHBP1 might play a promotion role in ESCC carcinogenesis by binding to PHB mRNA forming RNA duplex, consequently inducing PHB mRNA stability and transcription.