In the present study, a novel targeted c-MET and PD-1 BsAb was developed in our laboratory, that can bind human c-MET and PD-1 with high affinity and specificity, and induce the degradation of c-MET in multiple cancer cell types, including MKN45, a gastric cancer cell line, and A549, a lung cancer cell line. This evidence concerns the gene MET and gastric cancer.