CRP is a classical marker of inflammation that has be shown in persons with increased or sustained elevated CRP levels over a 6-year period has an increased risk of incident diabetes, coronary heart disease, ischemic stroke, heart failure, and mortality [42], moreover, the greatest hazard reduction in vascular events are observed in participants who achieved hs-CRP concentrations less than 1 mg/L in a prospective study [43]. The gene discussed is CRP; the disease is heart failure.