reported that mRNA and protein levels of FOXO6 were upregulated in gastric cancer tissues, FOXO6 overexpression promoted gastric cancer cell proliferation, moreover, FOXO6 induced C-myc expression by associating to HNF4 and mediating histone acetylation, and the dissociation of HDAC3 from the promoter of C-myc gene. The gene discussed is HNF4A; the disease is gastric cancer.