We analyzed whether P16, RASSF1A, APC, RARβ, DAPK, CDH13, and MGMT methylation status was correlated with clinicopathological characteristics of NSCLC, including age (≥60 years vs. ≤ 60years), gender (male vs. female), smoking behavior (smoking vs. nonsmoking), tumor stage (stage 0–2 vs. stage 3–4), and tumor histology (SCC vs. AC). This evidence concerns the gene APC and neoplasm.