A statistically significant relationship was found between RARβ methylation status and NSCLC in the MSP and qMSP method subgroups (OR = 10.02, P = 0.01; OR = 4.79, P = 0.02; respectively), but not for the nMSP method (P = 0.209). The gene discussed is RARB; the disease is non-small cell lung carcinoma.