After 4 weeks of therapy, the anti-uPA antibody significantly decreased the tumor weight compared with the control IgG group (end-stage tumor weight: 0.1838 ± 0.06376 g in anti-uPA group versus 0.4698 ± 0.05184 g in IgG control group) (Figure 7A, B). Here, PLAU is linked to neoplasm.