VEDT inhibited pluripotency transcription factors such as Nanog, Oct4, and Sox-2, Notch-1 receptor, metastasis marker MMP9 as well as Kras downstream signaling factors pAKT and pERK in pancreatic CSCs, indicating Kras signaling in pancreatic cancer stemness. This evidence concerns the gene POU5F1 and familial pancreatic carcinoma.